TB-500
Evidence score · 2 ref. PubMedLyophilized research compound · CAS 77591-33-4
Synthetic fragment of Thymosin β4 — in vitro study tool for cell migration and angiogenesis.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 77591-33-4
- Molecular weight
- 4963.4 g/mol
- Molecular formula
- C212H350N56O78S
Effects documented in the literature
TB-500 reproduces the active sequence of Thymosin β4 (Tβ4), an endogenous peptide involved in regulating the actin cytoskeleton. Studies (PMID 22315649, PMC3679553) describe sequestration of G-actin, modulating F-actin polymerization and promoting cell migration (keratinocytes, endothelial cells, stem cells). At the angiogenic level, TB-500 stimulates capillary tube formation by HUVECs and activates the PINCH-ILK-α-parvin pathway. Preclinical models describe accelerated skin, cardiac, and tendon healing, as well as modulation of pro-inflammatory cytokines. No direct hormonal effect has been reported. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2]
Background, storage, reconstitution
- Research background
- Synthetic peptide corresponding to an active fragment of Thymosin β4, used for the in vitro study of G-actin sequestration.
- Storage
- Lyophilized: −20 °C. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 10469335
- View on PubMed →[2] PubMedPMID 17600280