AHK-Cu
Evidence score · 1 ref. PubMedLyophilized research compound · CAS 147658-05-9
Copper tripeptide complex (Ala-His-Lys-Cu²⁺) — in vitro research tool for hair follicles and the extracellular matrix.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 147658-05-9
- Molecular weight
- 427.0 g/mol
- Molecular formula
- C16H25CuN7O3
Effects documented in the literature
AHK-Cu (Ala-His-Lys copper) is a copper tripeptide derived from the same family as GHK-Cu. In vitro studies (PMID 17703734, PMC8332470) showed marked stimulation of VEGF by dermal papilla cells, supporting peri-follicular angiogenesis. The complex increases keratinocyte and dermal fibroblast proliferation, lengthens the anagen phase of the hair cycle, and modulates the expression of TGF-β2 (a hair growth inhibitor). At the biochemical level, the studies describe activation of lysyl oxidase, a copper-dependent enzyme essential for collagen and elastin cross-linking. No systemic hormonal effect has been documented in in vitro models. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1]
Background, storage, reconstitution
- Research background
- Copper analog used as an experimental tool in dermal cell proliferation assays and modulation of VEGF in vitro.
- Storage
- Lyophilized: −20 °C, protected from light. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 17703734