SNAP-8
Evidence score · 1 ref. PubMedLyophilized research compound · CAS 868844-74-0
Octapeptide mimetic of the N-terminal domain of SNAP-25 — in vitro study tool for the SNARE complex.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 868844-74-0
- Molecular weight
- 910.03 g/mol
- Molecular formula
- C40H67N11O13
Effects documented in the literature
SNAP-8 is an octapeptide mimetic of the N-terminal domain of the SNAP-25 protein, an essential component of the SNARE complex that regulates the fusion of synaptic vesicles with the presynaptic membrane. In vitro studies (PMID 16641057) describe partial competition with endogenous SNAP-25, reducing SNARE complex formation and attenuating calcium-dependent neurotransmitter release. At the skin level, preclinical models report a transient reduction in facial muscle contractions (local myorelaxant effect) without systemic diffusion. No hormonal effect has been documented. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1]
Background, storage, reconstitution
- Research background
- Synthetic peptide used as an in vitro research tool for modulating neuronal exocytosis and the SNARE complex.
- Storage
- Lyophilized: −20 °C. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 16641057