Selank
Evidence score · 2 ref. PubMed / PMCLyophilized research compound · CAS 129954-34-3
Heptapeptide analog of tuftsin — in vitro study tool for GABAergic and anxiolytic pathways.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 129954-34-3
- Molecular weight
- 751.88 g/mol
- Molecular formula
- C33H57N11O9
Effects documented in the literature
Selank is a synthetic heptapeptide derived from tuftsin (Thr-Lys-Pro-Arg) stabilized by the addition of the tripeptide Pro-Gly-Pro. Studies (PMID 26228446, PMID 21390649) describe modulation of hippocampal BDNF and NGF expression, as well as potentiation of GABAergic transmission without direct affinity for the GABA-A receptor (unlike benzodiazepines). At the hormonal level, the studies observe a moderate reduction in cortisol under acute stress conditions, modulation of serotonin and norepinephrine, and an increase in endogenous enkephalin. Anxiolytic effects without sedation, antidepressant effects, and immunomodulatory effects (modulation of IL-6 and IFN-α) are documented in preclinical models and Russian clinical studies. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2]
Background, storage, reconstitution
- Research background
- Synthetic Russian peptide used as an experimental tool for modulating BDNF expression and the GABA system.
- Storage
- Lyophilized: −20 °C. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 31625062
- View on PMC →[2] PMCPMC5322660
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