NA Selank Amidate

Evidence score · 4 ref. PubMed / PMC

Lyophilized research compound · CAS 129954-34-3 (dérivé N-acétyl-amidé)

N-acetylated amidated form of Selank — in vitro research reagent for the study of peptide stability and neurotrophic pathways.

Vial format

Essential Accessories Pack

5 syringes + 5 swabs + 3 mL BAC water

€14.70

+€9.90

Premium Accessories Pack

10 syringes + 10 swabs + 3 mL BAC water

€22.70

+€15.90

Total

€139.00

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Research Use Only — Laboratory use exclusively

Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.

CAS No.: 129954-34-3 (dérivé N-acétyl-amidé)
Molecular weight: 779.92 g/mol
Molecular formula: C35H59N12O9

— Detailed scientific data

Effects documented in the literature

NA Selank Amidate is a structural modification of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) featuring an N-terminal acetyl group and C-terminal amidation. These two modifications increase peptide resistance to aminopeptidases and carboxypeptidases, extending the in vitro half-life relative to the native form. Studies on Selank (PMID 31625062, PMC5322660) show modulation of hippocampal BDNF and NGF expression, potentiation of GABAergic transmission without direct binding to the GABA-A receptor, and reduced cortisol under acute stress conditions. The N-acetyl-amidated form is studied as a more stable analog for in vitro protocols of neuroprotection, synaptic plasticity, and cytokine modulation (IL-6, IFN-α). Behaviorally, the literature reports anxiolytic effects without sedation, improved memory and attention, and mild immunomodulation. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3][4]

— Technical sheet

Background, storage, reconstitution

Research background: Synthetic peptide derived from Selank by N-terminal acetylation and C-terminal amidation, used as an experimental tool to compare metabolic stability, bioavailability, and modulation of BDNF expression in neuronal models.
Storage: Lyophilized: −20 °C, protected from light. Reconstituted: 2–8 °C, ≤ 28 days.
Reconstitution (lab): Reconstitute with sterile bacteriostatic water. Clear, colorless solution.→ Dilution calculator

— Bibliography