KPV

C-terminal tripeptide of α-MSH (Lys-Pro-Val) — in vitro study tool for the NF-κB pathway.

DosagePurity ≥ 99.0% (HPLC)

€74.00per 10 mg vial

i.e. €7.40 per mg

Out of stock

Shipped within 24 business hours from France, in neutral packaging.

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Janoshik certificateAnalysis no. 103336, purity 99.269% (12.09 mg)Commissioned by: third-party reportVerify

A question about this product?

Research Use Only — Laboratory use exclusively. Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.

Literature

What the literature describes

KPV is the C-terminal tripeptide of α-MSH (residues 11-13). Unlike full-length α-MSH, it has no significant affinity for melanocortin receptors and acts mainly intracellularly. Studies (PMID 18061177, PMID 12750433) describe inhibition of the NF-κB pathway, leading to reduced production of the pro-inflammatory cytokines IL-1β, TNF-α, IL-6, and IL-8. In vitro, KPV decreases neutrophil chemotaxis and IκB phosphorylation. Direct antimicrobial effects and modulation of the intestinal epithelial barrier (tight junction reinforcement) have also been documented. No hormonal effect has been reported. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]

Research background: Tripeptide used as an experimental tool for inhibiting the pro-inflammatory NF-κB pathway in cellular models.
Reconstitution (lab): Sterile bacteriostatic water. Dilution calculator

Chemical identity

What the vial contains

Reference data for the compound. Measured values appear on the Janoshik certificate, when published.

Research name: KPV
CAS No.: 67727-97-3
Molecular formula: C19H26N4O4
Molecular weight: 390.43 g/mol
Specified purity: ≥ 99.0% (HPLC)
Vial content: 10 mg
Storage: Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).
Database: PubChem

Independent analysis

Certificate for 10 mg

Report from Janoshik Analytical, an independent laboratory, for this exact dosage. The data below are taken from the report.

Janoshik certificate for this dosageCommissioned by: third-party report

Purity: 99.269% (12.09 mg)
Janoshik task: #103336
Tested: 06/02/2026

View the report Verify at Janoshik

Questions

Frequently asked questions

What does a vial of KPV contain?

Each vial contains lyophilised KPV, available in 10 mg. Purity ≥ 99.0% (HPLC), tested by an independent laboratory.

How can I check the purity of KPV?

The Janoshik Analytical (independent laboratory) certificates we hold are shown on this page for the matching dosage and can be verified directly on the laboratory's website. For a dosage without a published certificate, testing is in progress or available on request.

How should KPV be stored?

Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).

How is KPV reconstituted in the laboratory?

Sterile bacteriostatic water. The site's dilution calculator helps prepare the desired concentration.

Is KPV intended for human use?

No. KPV is a research reagent (RUO) intended exclusively for in vitro laboratory research. It is not intended for human or veterinary use, nor for diagnosing, preventing or treating any disease.

References