MOTS-c

Name: MOTS-c
Brand: Peptinium Labs
SKU: mots-c
Price: 69.00 EUR
Availability: InStock
Rating: 4.5 (2 reviews)

Mitochondrial peptide encoded by mitochondrial DNA (16S rRNA) — in vitro study tool for AMPK / glucose metabolism.

DosagePurity ≥ 99.0% (HPLC)

€69.00per 10 mg vial

i.e. €6.90 per mg

QuantityHalloween 2 + 1

3 vials: the cheapest item is free at checkout. Estimate for this product alone; the discount is applied at payment, across your whole cart.

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In stock

Shipped within 24 business hours from France, in neutral packaging.

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A question about this product?

Research Use Only — Laboratory use exclusively. Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.

Literature

What the literature describes

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by mitochondrial 12S ribosomal RNA. Studies (PMID 25738459, PMID 27216708) describe activation of the AMPK pathway independent of the AMP/ATP ratio, leading to increased muscle glucose uptake, stimulation of fatty acid β-oxidation, and inhibition of hepatic lipogenesis. At the hormonal level, the studies observe improved insulin sensitivity, reduced hyperglycemia induced by a high-calorie diet, and modulation of the folate-methionine axis via the AICAR pathway. Nuclear translocation of MOTS-c under metabolic stress conditions regulates the expression of antioxidant response genes. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]

Research background: Peptide of mitochondrial origin used as an in vitro research tool for the AMPK pathway and insulin sensitivity.
Reconstitution (lab): Sterile bacteriostatic water. Dilution calculator

Chemical identity

What the vial contains

Reference data for the compound. Measured values appear on the Janoshik certificate, when published.

Research name: MOTS-c
CAS No.: 1627580-64-6
Molecular formula: C82H133N21O22S2
Molecular weight: 1820.2 g/mol
Specified purity: ≥ 99.0% (HPLC)
Vial content: 10 mg
Storage: Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).
Database: PubChem

Independent analysis

Certificate for 10 mg

No Janoshik certificate has been published for 10 mg yet. We never show another dosage's report in its place.

No certificate published for this dosage

All published certificates

Questions

Frequently asked questions

What does a vial of MOTS-c contain?

Each vial contains lyophilised MOTS-c, available in 10 mg. Purity ≥ 99.0% (HPLC), tested by an independent laboratory.

How should MOTS-c be stored?

Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).

How is MOTS-c reconstituted in the laboratory?

Sterile bacteriostatic water. The site's dilution calculator helps prepare the desired concentration.

Is MOTS-c intended for human use?

No. MOTS-c is a research reagent (RUO) intended exclusively for in vitro laboratory research. It is not intended for human or veterinary use, nor for diagnosing, preventing or treating any disease.

References