MOTS-c
Evidence score · 3 ref. PubMed / PMCLyophilized research compound · CAS 1627580-64-6
Mitochondrial peptide encoded by mitochondrial DNA (16S rRNA) — in vitro study tool for AMPK / glucose metabolism.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 1627580-64-6
- Molecular weight
- 1820.2 g/mol
- Molecular formula
- C82H133N21O22S2
Effects documented in the literature
MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by mitochondrial 12S ribosomal RNA. Studies (PMID 25738459, PMC4753972) describe activation of the AMPK pathway independent of the AMP/ATP ratio, leading to increased muscle glucose uptake, stimulation of fatty acid β-oxidation, and inhibition of hepatic lipogenesis. At the hormonal level, the studies observe improved insulin sensitivity, reduced hyperglycemia induced by a high-calorie diet, and modulation of the folate-methionine axis via the AICAR pathway. Nuclear translocation of MOTS-c under metabolic stress conditions regulates the expression of antioxidant response genes. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]
Background, storage, reconstitution
- Research background
- Peptide of mitochondrial origin used as an in vitro research tool for the AMPK pathway and insulin sensitivity.
- Storage
- Lyophilized: −20 °C. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 27216708
- View on PubMed →[2] PubMedPMID 34520826
- View on PMC →[3] PMCPMC8376922
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