MOTS-c

Effects documented in the literature

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by mitochondrial 12S ribosomal RNA. Studies (PMID 25738459, PMC4753972) describe activation of the AMPK pathway independent of the AMP/ATP ratio, leading to increased muscle glucose uptake, stimulation of fatty acid β-oxidation, and inhibition of hepatic lipogenesis. At the hormonal level, the studies observe improved insulin sensitivity, reduced hyperglycemia induced by a high-calorie diet, and modulation of the folate-methionine axis via the AICAR pathway. Nuclear translocation of MOTS-c under metabolic stress conditions regulates the expression of antioxidant response genes. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]