Melanotan II
Evidence score · 3 ref. PubMedLyophilized research compound · CAS 121062-08-6
Synthetic α-MSH analog — reagent for in vitro study of MC1R / MC4R receptors.
Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.
- CAS No.
- 121062-08-6
- Molecular weight
- 1024.18 g/mol
- Molecular formula
- C50H69N15O9
Effects documented in the literature
Melanotan II is a non-selective cyclic analog of α-MSH that activates MC1R, MC3R, MC4R, and MC5R. At the hormonal and neurobiological level, studies (PMID 8637402, PMID 15262693) characterized stimulation of melanogenesis via MC1R (pigmentation), as well as activation of hypothalamic MC3R/MC4R pathways involved in the regulation of appetite (documented anorexigenic effect), energy expenditure, and erectile function (via pro-opiomelanocortin neurons modulating nitric oxide at the paraventricular level). MC4R activation alters leptin secretion and satiety signaling. Effects observed in preclinical models include increased eumelanin, reduced food intake, and stimulation of sexual behaviors in rodents. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]
Background, storage, reconstitution
- Research background
- Peptide used as a non-selective reference ligand in the characterization of melanocortin receptors.
- Storage
- Lyophilized: −20 °C. Reconstituted: 2–8 °C.
- Reconstitution (lab)
- Sterile bacteriostatic water.→ Dilution calculator
PubMed references
- View on PubMed →[1] PubMedPMID 9679884
- View on PubMed →[2] PubMedPMID 11739247
- View on PubMed →[3] PubMedPMID 17584134