Melanotan I

Synthetic α-MSH analog (afamelanotide) — in vitro study tool for the MC1R receptor.

DosagePurity ≥ 99.0% (HPLC)

€64.00per 10 mg vial

i.e. €6.40 per mg

QuantityHalloween 2 + 1

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Shipped within 24 business hours from France, in neutral packaging.

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Janoshik certificateAnalysis no. 75760, purity 99.762% / 99.571%Commissioned by: third-party reportVerify

A question about this product?

Research Use Only — Laboratory use exclusively. Not intended for veterinary, diagnostic or therapeutic use. No indication for in vivo use. To be handled exclusively by qualified personnel.

Literature

What the literature describes

Melanotan I (afamelanotide) is an α-MSH (alpha-melanocyte stimulating hormone) analog with marked selectivity for the MC1R receptor. Studies (PMID 15262693, PMID 9113347, PMC11664455) show that activation of MC1R on melanocytes stimulates adenylate cyclase, increases cAMP, and activates the MITF → tyrosinase pathway, the main rate-limiting enzyme of melanogenesis. The result is increased production of eumelanin (a photoprotective pigment) rather than pheomelanin. At the hormonal level, unlike non-selective ligands, MT-I shows reduced affinity for MC3R/MC4R, limiting effects on appetite or sexual function. Clinical work has documented a reduction in UV-induced damage in photoprotection protocols for rare skin conditions (erythropoietic protoporphyria). These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2]

Research background: Peptide used as a reference ligand for the characterization of the melanocortin 1 receptor on pigment cells.
Reconstitution (lab): Sterile bacteriostatic water. Dilution calculator

Chemical identity

What the vial contains

Reference data for the compound. Measured values appear on the Janoshik certificate, when published.

Research name: Melanotan I
CAS No.: 75921-69-6
Molecular formula: C78H111N21O19
Molecular weight: 1646.85 g/mol
Specified purity: ≥ 99.0% (HPLC)
Vial content: 10 mg
Storage: Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).
Database: PubChem

Independent analysis

Certificate for 10 mg

Report from Janoshik Analytical, an independent laboratory, for this exact dosage. The data below are taken from the report.

Janoshik certificate for this dosageCommissioned by: third-party report

Purity: 99.762% / 99.571%
Janoshik task: #75760
Tested: 22/08/2025

View the report Verify at Janoshik

Questions

Frequently asked questions

What does a vial of Melanotan I contain?

Each vial contains lyophilised Melanotan I, available in 10 mg. Purity ≥ 99.0% (HPLC), tested by an independent laboratory.

How can I check the purity of Melanotan I?

The Janoshik Analytical (independent laboratory) certificates we hold are shown on this page for the matching dosage and can be verified directly on the laboratory's website. For a dosage without a published certificate, testing is in progress or available on request.

How should Melanotan I be stored?

Lyophilized: refrigerated (2–8 °C) from receipt, protected from light, or at −20 °C for long-term storage; it tolerates a few days of shipping at room temperature with no expected degradation. Reconstituted: refrigerated (2–8 °C).

How is Melanotan I reconstituted in the laboratory?

Sterile bacteriostatic water. The site's dilution calculator helps prepare the desired concentration.

Is Melanotan I intended for human use?

No. Melanotan I is a research reagent (RUO) intended exclusively for in vitro laboratory research. It is not intended for human or veterinary use, nor for diagnosing, preventing or treating any disease.

References