Cagrilintide

Cagrilintide is a long-acting analog of human amylin, stabilized by substitution of aggregation-prone residues and by acylation of a C20 diacid chain enabling reversible binding to serum albumin. Published work (PMID 34288673, PMID 37364590) describes non-selective activation of calcitonin receptor (CTR) complexes associated with RAMP1-3, forming the AMY1R, AMY2R, and AMY3R receptors, with Gαs → adenylate cyclase → cAMP coupling and prolonged signaling linked to slow receptor dissociation. In cellular and preclinical models, the literature (PMID 32634450) documents activation of neurons in the area postrema and nucleus tractus solitarius, as well as modulation of hypothalamic POMC/CART pathways. Its signalling pathway, that of amylin, is distinct from the incretin pathway of GLP-1 agonists: it is used as a tool to compare both pathways in research. These data come from the scientific literature and are provided strictly for informational purposes in a research context. This product is not intended for veterinary, diagnostic or therapeutic use and is not recommended for any use outside a scientific, professional and research setting. [1][2][3]

Research background

Synthetic analog of human amylin used as a pharmacological tool for in vitro characterization of amylin (AMY1-3R) and calcitonin (CTR) receptor signaling.

Reconstitution (lab)

Sterile bacteriostatic water — mix gently, do not shake. Dilution calculator